Intracytoplasmic Sperm Injection (ICSI)

IVF variant in which a single sperm is injected directly into each mature egg. Used for male-factor and prior fertilization failure.

Overview

ICSI is used within an IVF cycle when sperm parameters or prior fertilization outcomes suggest that conventional insemination may under-perform. A single sperm is selected and injected into each mature egg.

Common Indications

  • Severe or moderate male-factor infertility
  • Prior fertilization failure with conventional IVF
  • Cryopreserved sperm with limited count
  • Surgical sperm retrieval

How It Works

  1. Standard IVF stimulation and retrieval.
  2. Embryologist selects individual sperm.
  3. Each mature egg is injected under microscopy.
  4. Culture, transfer, and cryopreservation as with standard IVF.

Considerations

  • ICSI improves fertilization rate in appropriate cases but does not overcome underlying egg or embryo quality issues.
  • Should be used based on documented indication, not as a routine add-on.

Educational content only. No procedure guarantees an outcome. Decisions must be made with a licensed specialist.

Related

Medical Reviewer

Hospital Cyntar Medical Team

Reproductive Medicine — Tijuana, Mexico

Reviewer profile & board
Last Reviewed

November 2025

Next review due: November 2026

Reviewed at least annually against current peer-reviewed literature and professional society guidance.

What Review Covered

Clinical accuracy, alignment with ASRM/ESHRE/WHO guidance, balanced presentation of benefits and limitations, and plain-language readability.

Medical Disclaimer: This content is for educational and informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. No fertility treatment can guarantee pregnancy or live birth. Individual outcomes vary. Always consult a qualified fertility specialist regarding your specific medical situation.